0081 Physiologic anatomy, use of Infra-Red Thermography in Hypersomnia

Abstract Introduction In the words of Michel Salmon, " Between anatomy and physiology there is room for a functional physiologic “. This concept was applied to analyze our (1) Sleep Research 21, 1992,341 (2) 22, 1993, 363, (3) SLEEP 31, 2008, A219 publications on patients with Hypersomnia who had intracranial extracranial blood flow evaluations. Methods For “Functional Anatomy”, Intracranial cerebral done Xenon 133 inhalation. “Physiologic Extracranial facial Imaging, Infra-Red thermography done. 1992,3 2008 data classified: Groups I, II III. Group I study, 5% CO2 study 5 % 100 Oxygen III Response interpretation: Normal response CO2, vasodilation. 100% / hyperoxia, vasoconstriction. considered as normal or abnormal, if absent paradoxical. Results I: All three inhalation, Functional vasomotor normal. Physiological Anatomy abnormal. II, study. 8 patients. response, 7/8 vasoconstriction, abnormal response. challenge, 4/8 no III: anatomy. 7 tested challenge. 6/7 (1 4 2 vasodilation). Total 18 in all groups, physiological anatomy/ 16/18, (Group = 3, 7, 6) Conclusion hypersomnia testing, Anatomy, vasomotion 3/3 hypercarbia Physiologic using Thermography image (not coupled metabolism) 16/18 inhalation used contrast agents well tolerated facilitates imaging dysfunction flow, trigeminal angiosomes, which can be correlated hypersomnia. Association between system hypocretin receptor 1 gene HCRTR1 has been reported. Support (If Any) None.